Formulary: Drug Doses

This list is not exhaustive.
Consult appropriate reference for more details.

Ampicillin IV/IM 25 mg/kg
50 mg/kg
< 7 days:
BD if < 2 kg
TDS if > 2kg
> 7 days:
BD if < 1.2 kg
TDS if 1.2-2 kg
QID if > 2 kg
Sepsis, Meningitis
Adrenaline IV 0.1ml/kg of 1:10000 STAT CPR
Aminophylline PO Loading dose: 6 mg/kg
Maintenance dose: 2.5 mg/kg
Respiratory stimulants (Apnoea)
Preparation and dosing
Benzylpenicillin IV 50000 IU/kg in Sepsis, Pneumonia, Syphilis etc.
100000 IU/kg in Meningitis
BD if <7 days
QID if > 7 days
Sepsis, Syphilis, Meningitis
Ceftriaxone IV Meningitis or Severe Infection: 100 mg/kg
Other infections 50 mg/kg
OD Sepsis, Meningitis
Bloody diarrhoea: 5 days
Chlorhexidine (CHX) locally to the tip of the cord, the stump and around the base of the stump STAT Apply CHX. once within 24 hours after the birth, but preferably in the first 2 hrs
Ciprofloxacin PO 7.5mg/kg OD Bloody diarrhoea: 3 days
Cotrimoxazole PO CPT: Cotrimoxazole preventative therapy:
120 mg OD (dispersible paediatric tablet or ¼ adult tablet)
High dose in PJP: 120mg/kg/day given 8 hourly for 3 weeks, maximum dose 1920mg/day
Diazepam PR 0.1mg/kg
0.3 ml of 10 mg/2 ml solution (<4 kg)
STAT Convulsion.
CAVE resp. depression
Only give if beyond 2 weeks
(Flu)cloxacillin IV/IM 50 mg/kg
BD if < 7 days
QID if > 7 days
Skin infections.
Gentamicin IV/IM LBW < 7 days: 3 mg/kg
Term < 7 days: 5 mg/kg
> 7 days 7.5 mg/kg
OD Sepsis, Meningitis
Oto- and nephrotoxicity
Iron supplements PO 2–4 mg/kg
Syrup usually contains 50mg iron in 5 mls or 10mg per ml
OD Preterm neonates from 2 weeks if tolerating full enteral feeds until 6 months of age
Isoniazid PO Dose accuratly if syrup is available: 10 mg/kg/day
If only tablets are available:
< 2500g: 25mg (1/4 tablet) every 24 hours
2500-5000g: 50mg (1/2 tablet) every 24 hours
OD Exposure to TB
Metronidazole IV 7.5 mg/kg TDS Intra-abdominal infections (e.g. NEC)
Multivitamin preparation PO 0.3-0.6ml (5-10 drops)/ day
= vitamin A of 1000 IU/day and vitamin D 400 iu/day)
OD Preterm neonates if tolerating full enteral feeds until 6 months of age
Nevirapine oral <2500g: 1 ml syrup
>2500g: 1.5 ml syrup
OD For six weeks in HIV exposed neonates
Paraldehyde IM 0.2mls/kg
(2kg: 0.4mls, 3kg: 0.6mls, 4kg: 0.8mls)
can be repeated 1 x after 10 min
Do not leave in plastic syringe for longer than 10-15 min.
Should not be given IV. Preferable to give rectally
PR 0.4mls/kg
(2kg: 0.8mls, 3kg: 1.2mls, 4kg: 1.6mls)
Phenobarbitone IM Loading dose: 20 mg/kg
if < 2kg: 0.2 mls
if > 2 kg: 0.3 mls
can be repeated 1x after 10 min
* Volumes assumes that the Phenobarbitone being used is of 200mg/ml preparation.
PO Maintenance dose: 2.5-5 mg/kg nocte
Prednisolone PO in PJP: 2mg/kg OD for 7 days, than wean off over 2 weeks (1mg/kg/day for 7 days, 0.5mg/kg/day for a further 7 days
Tetracycline Eye Ointment (TEO) local both eyes once after birth STAT at birth
Vitamin K IM preterm: 0.5 mg
term: 1 mg
STAT at birth, Routine care, >Preterms/LBW
slowly IV Neonatal Vit K deficiency bleeding 1 mg STAT to TDS
Zinc PO 1/2 tablet (10 mg) per day for 10 days OD Diarrhoea